Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?
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چکیده
منابع مشابه
Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?
The lysosomal aspartic protease cathepsin D (cath-D) is overexpressed and hyper-secreted by epithelial breast cancer cells. This protease is an independent marker of poor prognosis in breast cancer as it is correlated with the incidence of clinical metastasis. In normal cells, cath-D is localized in intracellular vesicles (lysosomes and endosomes). In cancer cells, overexpressed cath-D accumula...
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The aspartic protease cathepsin D (CD) is a key mediator of induced-apoptosis and its proteolytic activity has been generally involved in this event. During apoptosis, CD is translocated to the cytosol. Since CD is one of the lysosomal enzymes that requires a more acidic pH to be proteolytically-active relative to the cysteine lysosomal enzymes such as cathepsin-B and cathepsin-L, it is therefo...
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ژورنال
عنوان ژورنال: Biochimie
سال: 2010
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2010.05.009